Hagan P L, Halpern S E, Stern P, Dabbs J, Gordon R
Invest Radiol. 1980 Nov-Dec;15(6):496-501. doi: 10.1097/00004424-198011000-00006.
The smallest quantity of carrier Ga and Mn necessary to initiate and maximize a carrier effect was studied in the Morris 7777 rat hepatoma model. The quantity needed for a maximum response did not appear to adversely effect the rats. Not all tissues were equally affected at the same plasma concentrations. If carrier Ga was administered 2 hours following 67Ga injection and the rats sacrificed 30 minutes later, a dramatic change occurred in background activity, which was more pronounced in healthy than malignant tissues. Early viable and nonviable tumor/background ratios were improved by this technique. The data suggest that the use of carrier Ga and Mn might improve early lesion/background ratios in patients. This could be of use if tumor imaging were undertaken with 68Ga or 52mMn with positron detector systems.
在莫里斯7777大鼠肝癌模型中，研究了引发载体效应并使其最大化所需的最小量载体镓（Ga）和锰（Mn）。产生最大反应所需的量似乎不会对大鼠产生不利影响。在相同的血浆浓度下，并非所有组织都受到同等程度的影响。如果在注射67Ga后2小时给予载体Ga，并在30分钟后处死大鼠，背景活性会发生显著变化，这种变化在健康组织中比在恶性组织中更为明显。通过该技术，早期存活和非存活肿瘤/背景比值得到了改善。数据表明，使用载体Ga和Mn可能会提高患者早期病变/背景比值。如果使用正电子探测器系统进行68Ga或52mMn肿瘤成像，这可能会有帮助。
