Halpern S E, Hagan P L, Chauncey D, McKegney M, Bernstein K
Invest Radiol. 1979 Nov-Dec;14(6):482-92. doi: 10.1097/00004424-197911000-00007.
Buffalo rats bearing thigh-implanted strain-7777 Morris hepatomas were used as a model for studying the effect of carrier material on the body distribution, tumor uptake, excretion, and tumor-to-background ratios of 67Ga and 54Mn. An effort was also made to observe the changes in 67Ga and 54Mn concentrations induced by carrier in viable tumor and skeletal muscle, relative to their interstitial fluid space. This value is referred to as the Tissue Distribution Index. Carrier manipulation resulted in striking changes in the distribution of the two ions from the carrier-free state. The data also indicated a difference in the pharmacodynamics of 67Ga and 54Mn in malignant and healthy tissues which could be of importance to nuclear medicine and oncology.
将携带植入大腿的7777株Morris肝癌的水牛大鼠用作模型，以研究载体材料对67Ga和54Mn的体内分布、肿瘤摄取、排泄以及肿瘤与本底比值的影响。还努力观察载体在存活肿瘤和骨骼肌中诱导的67Ga和54Mn浓度相对于其组织间隙液空间的变化。该值称为组织分布指数。载体操作导致两种离子在无载体状态下的分布发生显著变化。数据还表明，67Ga和54Mn在恶性和健康组织中的药效学存在差异，这可能对核医学和肿瘤学具有重要意义。
