Hagan P L, Halpern S E, Stern P H, Gordon R M, Dabbs J E
Invest Radiol. 1982 Jan-Feb;17(1):53-60. doi: 10.1097/00004424-198201000-00011.
The effect of Fe3+ citrate on carrier-free 67Ga and 59Fe kinetics was studied in a Buffalo rat-Morris 7777 hepatoma model. Two mg Fe3+ citrate/Kg were administered intravenously in a variety of time sequences, prior to and following the tracers, and the rats were killed at 4 or 24 hours. 67Ga concentrations could be increased in tumor and decreased in most normal tissues. Administering Fe3+ both one half hour before and 2 hours after the tracers produced 67Ga values equivalent to 72-hour carrier-free values after 4 hours, while simultaneously decreasing gut secretion and increasing urinary excretion. The 59Fe and 67Ga kinetics suggested that events at both vascular and cellular levels were responsible for these changes. This study demonstrated the potential utility of Fe3+ citrate for improving both conventional 67Ga and positron (68Ga) imaging of tumors.
在布法罗大鼠 - 莫里斯7777肝癌模型中研究了柠檬酸铁（Fe3+）对无载体67Ga和59Fe动力学的影响。以多种时间顺序在注射示踪剂之前和之后静脉注射2mg/kg柠檬酸铁（Fe3+），并在4小时或24小时处死大鼠。肿瘤中67Ga浓度可升高，而大多数正常组织中67Ga浓度降低。在示踪剂注射前半小时和注射后2小时给予Fe3+，4小时后产生的67Ga值相当于72小时无载体值，同时减少肠道分泌并增加尿排泄。59Fe和67Ga动力学表明，血管和细胞水平的事件均导致了这些变化。本研究证明了柠檬酸铁（Fe3+）在改善传统67Ga和正电子（68Ga）肿瘤成像方面的潜在效用。
