Hagan P L, Halpern S E, Stern P, Dabbs J, Gordon R
Invest Radiol. 1981 May-Jun;16(3):229-33. doi: 10.1097/00004424-198105000-00014.
The intravenous administration of Fe+3 -citrate (1.6 mg/kg body weight) was demonstrated to alter the concentration of carrier-free 67Ga and 54Mn in malignant and healthy tissues of the rat, Morris 7777 hepatoma model. When the Fe+3 was injected 2 hours before, simultaneously with, or 2 hours after 67Ga (and the rats sacrificed 4 hours after injection), the 67Ga in most normal tissues decreased, and the viable tumor concentrations increased by 135, 24, and 47%, respectively. Twenty-four hours after a simultaneous administration of Fe+3 and 67Ga, egress of 67Ga from the tumor was much less than from the healthy tissues. These changes resulted in significant improvements in viable tumor to background ratios, especially at 4 hours. These changes induced in the distribution of the two tracers by Fe+3 indicate that some kinetic characteristics are shared. This is discussed in the light of their response to carrier Ga and Mn. The use of Fe+3 shows promise as a means of improving tumor/background ratios for 68Ga and 52mMn, two short-lived positron emitters that can be used with positron scanners. Gallium-67 imaging may also be improved by these techniques. The Fe+3 increases excretion of 67Ga from the animal, and this could result in a lower radiation dose to a patient.
在大鼠Morris 7777肝癌模型中，静脉注射柠檬酸铁（III）（1.6毫克/千克体重）被证明会改变无载体67Ga和54Mn在恶性组织和健康组织中的浓度。当在注射67Ga前2小时、同时或注射67Ga后2小时注射铁（III）（并在注射后4小时处死大鼠）时，大多数正常组织中的67Ga含量降低，而存活肿瘤中的浓度分别增加了135%、24%和47%。在同时注射铁（III）和67Ga后24小时，67Ga从肿瘤中的排出量远低于从健康组织中的排出量。这些变化导致存活肿瘤与背景的比值显著提高，尤其是在4小时时。铁（III）引起的这两种示踪剂分布变化表明它们具有一些共同的动力学特征。根据它们对载体Ga和Mn的反应对此进行了讨论。使用铁（III）有望作为提高68Ga和52mMn肿瘤/背景比值的一种方法，这两种短寿命正电子发射体可与正电子扫描仪一起使用。这些技术也可能改善镓-67成像。铁（III）增加了动物体内67Ga的排泄，这可能会降低患者的辐射剂量。
