Halpern S E, Hagan P, Stern P, Gordon R, Dabbs J
Invest Radiol. 1981 Mar-Apr;16(2):120-5. doi: 10.1097/00004424-198103000-00008.
Attempts were made to increase the viable tumor concentration of 54Mn and 67Ga in a rat hepatoma model by administering rat angiotensin, tolazoline, and salicylates. Salicylates increased the tumor concentrations of 54Mn and improved 65Mn viable tumor/background ratios. 67Ga was not affected by the salicylates. The salicylate effect appeared to be mediated by intracellular mechanisms rather than alterations in plasma protein binding. Rat angiotensin slightly increased the concentrations of 67Ga in the tumors but not enough to suggest that it would be useful clinically. Tolazoline did not increase tumor uptake of the tracers.
通过给予大鼠血管紧张素、妥拉唑啉和水杨酸盐，试图在大鼠肝癌模型中提高54Mn和67Ga的活肿瘤浓度。水杨酸盐提高了54Mn的肿瘤浓度，并改善了65Mn活肿瘤/本底比值。67Ga不受水杨酸盐影响。水杨酸盐的作用似乎是由细胞内机制介导的，而非血浆蛋白结合的改变。大鼠血管紧张素略微提高了肿瘤中67Ga的浓度，但不足以表明其在临床上有用。妥拉唑啉未增加示踪剂的肿瘤摄取。
