Ryall R L, Ryall R G, Marshall V R
Invest Urol. 1981 Mar;18(5):396-400.
We used a simple theoretical model to stimulate the changes in particle size distribution that occur when crystals grow, or disaggregate to a defined extent. The change in total particle volume was used as an index of growth, whereas aggregation and disaggregation were expressed as the change in total particle number. Indices of inhibition of growth and of aggregation in hypothetical test cases were calculated in relation to a control and compared with the inhibition index derived by the standard method of comparing the distribution of particle volume around a given arbitrary diameter on the particle distribution curve. We concluded that the expression of particle growth and aggregation in terms of total volume and number respectively is a preferable alternative to the standard technique.
我们使用了一个简单的理论模型来模拟晶体生长或在一定程度上解聚时发生的粒度分布变化。总颗粒体积的变化被用作生长指标，而聚集和解聚则用总颗粒数的变化来表示。在假设的测试案例中，生长抑制和聚集抑制指标是相对于对照计算的，并与通过在颗粒分布曲线上围绕给定任意直径比较颗粒体积分布的标准方法得出的抑制指标进行比较。我们得出结论，分别用总体积和数量来表示颗粒生长和聚集是标准技术的一种更好的替代方法。
