Ryall R L, Bagley C J, Marshall V R
Invest Urol. 1981 Mar;18(5):401-5.
The growth and aggregation of calcium oxalate seed crystals in a metastable solution of this salt were assessed separately by using the Coulter counter to measure the net increase in total crystal volume and the percentage change in total crystal number respectively. The value of assessing crystal growth and aggregation in these terms was shown by using these parameters to measure the inhibitory effect of a normal human urine. Independent assessment of growth and aggregation enabled a more accurate interpretation of experimental events than was possible by considering the two processes in combination. The method therefore has the potential of improving the discrimination between the inhibitory activities of different urines.
通过使用库尔特计数器分别测量草酸盐亚稳溶液中草酸钙籽晶的生长和聚集情况，以测定晶体总体积的净增加量和晶体总数的百分比变化。通过使用这些参数来测量正常人尿液的抑制作用，证明了以这些指标评估晶体生长和聚集的价值。与将这两个过程结合起来考虑相比，对生长和聚集进行独立评估能够更准确地解释实验结果。因此，该方法有可能提高对不同尿液抑制活性的区分能力。
