Drenth J
J Biol Chem. 1981 Mar 25;256(6):2601-2.
The positions of the half-cystines in the hormone carrier neurophysin are compared with those in three cystine-rich plant proteins. This suggests that neurophysin is a molecule of two domains with each very similar in structure to the domains in wheat germ agglutinin. It is further proposed that in proneurophysin the hormone (oxytocin or vasopressin) is covalently linked to the COOH terminus of neurophysin.
将激素载体神经垂体激素运载蛋白中半胱氨酸的位置与三种富含胱氨酸的植物蛋白中的半胱氨酸位置进行了比较。这表明神经垂体激素运载蛋白是一个由两个结构域组成的分子,每个结构域的结构与麦胚凝集素中的结构域非常相似。进一步推测,在神经垂体激素原中,激素(催产素或加压素)与神经垂体激素运载蛋白的COOH末端共价连接。