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神经垂体素的结构。

The structure of neurophysin.

作者信息

Drenth J

出版信息

J Biol Chem. 1981 Mar 25;256(6):2601-2.

PMID:7204368
Abstract

The positions of the half-cystines in the hormone carrier neurophysin are compared with those in three cystine-rich plant proteins. This suggests that neurophysin is a molecule of two domains with each very similar in structure to the domains in wheat germ agglutinin. It is further proposed that in proneurophysin the hormone (oxytocin or vasopressin) is covalently linked to the COOH terminus of neurophysin.

摘要

将激素载体神经垂体激素运载蛋白中半胱氨酸的位置与三种富含胱氨酸的植物蛋白中的半胱氨酸位置进行了比较。这表明神经垂体激素运载蛋白是一个由两个结构域组成的分子,每个结构域的结构与麦胚凝集素中的结构域非常相似。进一步推测,在神经垂体激素原中,激素(催产素或加压素)与神经垂体激素运载蛋白的COOH末端共价连接。

相似文献

1
The structure of neurophysin.神经垂体素的结构。
J Biol Chem. 1981 Mar 25;256(6):2601-2.
2
Crystal structure of the neurophysin-oxytocin complex.神经垂体激素运载蛋白-催产素复合物的晶体结构。
Nat Struct Biol. 1996 Feb;3(2):163-9. doi: 10.1038/nsb0296-163.
3
Fluorescence studies of native and modified neurophysins. Effects of peptides and pH.
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Complete amino acid sequence of goose VLDV-neurophysin. Traces of a putative gene conversion between promesotocin and provasotocin genes.
Int J Pept Protein Res. 1990 Nov;36(5):457-64. doi: 10.1111/j.1399-3011.1990.tb01306.x.
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[Common precursors of neurohypophysial hormones and neurophysins].[神经垂体激素和神经垂体素的常见前体]
Ann Endocrinol (Paris). 1988;49(4-5):377-83.
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Characterization of porcine neurophysin. III. Its resemblance and possible relationship to porcine neurophysin I.猪神经垂体素的特性。III. 它与猪神经垂体素I的相似性及可能的关系。
J Biol Chem. 1976 May 10;251(9):2735-9.
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Complete amino acid sequence of a VLDV-type neurophysin from ostrich differs markedly from known mammalian neurophysins.鸵鸟的一种VLDV型神经垂体素的完整氨基酸序列与已知的哺乳动物神经垂体素显著不同。
Int J Pept Protein Res. 1987 Nov;30(5):634-45. doi: 10.1111/j.1399-3011.1987.tb03374.x.
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Interactions of oxytocin and vasopressin with bovine neurophysins I and II. Effects of hormone binding on the protein quaternary structure: a simple model.催产素和加压素与牛神经垂体素I和II的相互作用。激素结合对蛋白质四级结构的影响:一个简单模型。
J Biol Chem. 1976 Jul 10;251(13):3965-71.
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Subcellular organization of neurophysins, oxytocin, (8-lysine)-vasopressin and adenosine triphosphatase in porcine posterior pituitary lobes.猪垂体后叶中神经垂体素、催产素、(8-赖氨酸)-加压素和三磷酸腺苷酶的亚细胞组织
Biochem J. 1973 Mar;132(3):361-71. doi: 10.1042/bj1320361.
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Sequence redesign and the assembly mechanism of the oxytocin/bovine neurophysin I biosynthetic precursor.催产素/牛神经垂体素I生物合成前体的序列重新设计及组装机制
J Biol Chem. 1987 Sep 25;262(27):12962-9.

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Complete sequence analysis of cDNA clones encoding rat whey phosphoprotein: homology to a protease inhibitor.
编码大鼠乳清磷蛋白的cDNA克隆的完整序列分析:与一种蛋白酶抑制剂的同源性
Proc Natl Acad Sci U S A. 1982 Jul;79(13):3987-91. doi: 10.1073/pnas.79.13.3987.
4
Comparative sequence analysis of the mRNAs coding for mouse and rat whey protein.编码小鼠和大鼠乳清蛋白的mRNA的比较序列分析。
Nucleic Acids Res. 1982 Jun 25;10(12):3733-44. doi: 10.1093/nar/10.12.3733.
5
Mouse whey acidic protein is a novel member of the family of 'four-disulfide core' proteins.小鼠乳清酸性蛋白是“四二硫键核心”蛋白家族的一个新成员。
Nucleic Acids Res. 1982 Apr 24;10(8):2677-84. doi: 10.1093/nar/10.8.2677.
6
On the genetic and structural similarities between the squash seeds polypeptide trypsin inhibitors and wheat germ agglutinin.
Mol Cell Biochem. 1984;60(2):159-61. doi: 10.1007/BF00222486.
7
Comparison of the whey acidic protein genes of the rat and mouse.大鼠和小鼠乳清酸性蛋白基因的比较。
Nucleic Acids Res. 1984 Nov 26;12(22):8685-97. doi: 10.1093/nar/12.22.8685.
8
Complete assignment of neurophysin disulfides indicates pairing in two separate domains.神经垂体激素运载蛋白二硫键的完全配对表明其在两个独立结构域中配对。
Proc Natl Acad Sci U S A. 1989 Jan;86(2):429-33. doi: 10.1073/pnas.86.2.429.