Riambau E, Lloveras J, Aubía J, Masramón J, García C, Orfila M A, Llorach M
J Dial. 1980;4(4):203-17. doi: 10.3109/08860228009065344.
Clinical studies were made in order to determine the effects of intraperitoneal nitroprusside on the peritoneal clearances according to different frequencies of drug administration. An important increase of urea and creatinine clearances with 3.75 mg of nitroprusside per liter of dialysis solution was observed. The maximum effects were observed after four consecutive exchanges with the drug; its effects were maintained all through the peritoneal dialysis session and in some cases increased when alternative series of four exchanges with and without drug were carried on. The significative higher increase of the big solutes clearances suggests a vasodilator action of nitroprusside which should be also reflected on an increase of the middle size molecules clearances. Clinical tolerance was excellent and the blood pressure variations were negligible.
为了根据不同的药物给药频率确定腹腔内硝普钠对腹膜清除率的影响，进行了临床研究。观察到每升透析液中加入3.75毫克硝普钠时，尿素和肌酐清除率有显著提高。连续四次使用该药物交换后观察到最大效果；其效果在整个腹膜透析过程中持续存在，并且在某些情况下，当交替进行四次有药和无药交换时，效果会增强。大溶质清除率的显著更高增加表明硝普钠具有血管舒张作用，这也应反映在中等大小分子清除率的增加上。临床耐受性良好，血压变化可忽略不计。
