Kurucz J, Charbonneau R, Kurucz A, Ramsey P
J Am Geriatr Soc. 1981 Apr;29(4):158-63. doi: 10.1111/j.1532-5415.1981.tb01758.x.
In a randomized blind study of 69 mental hospital patients over 50 years of age, a highly significant correlation was observed between the clinical symptoms of organic brain disease and the quantity of senile plaques found in the brains at autopsy. A stepwise multiple regression analysis indicated that independent significant predictors of the quantity of plaques were the level or disorientation and the age of the patient. Additional clinical tests for intellectual deterioration, affect lability, and impairment of memory and judgment did not improve the predictive ability. The correlation between incidental pathologic changes unrelated to the senile form of cerebral degeneration and the clinical symptoms was highly significant, though not obvious. Only after removal of the effect of the quantity of plaques on the clinical symptoms (multiple regression analysis) did the effect of other pathologic processes become evident. A significant one-way fixed-effect relationship was noted between increasing quantity of symptoms and increasing quantity of plaques in 48 cases of senile dementia correctly diagnosed by the psychiatry staff. In the control group of 21 patients without senile dementia, the quantity of plaques was correlated with the age of the patients but not with their clinical symptoms.
在一项针对69名50岁以上精神病院患者的随机盲法研究中，观察到器质性脑疾病的临床症状与尸检时大脑中发现的老年斑数量之间存在高度显著的相关性。逐步多元回归分析表明，斑块数量的独立显著预测因素是定向障碍程度和患者年龄。针对智力衰退、情感易变性以及记忆和判断力损害的额外临床测试并未提高预测能力。与老年型脑变性无关的偶然病理变化与临床症状之间的相关性虽不明显，但高度显著。只有在消除斑块数量对临床症状的影响（多元回归分析）之后，其他病理过程的影响才变得明显。在精神科工作人员正确诊断的48例老年痴呆症病例中，症状数量增加与斑块数量增加之间存在显著的单向固定效应关系。在21名无老年痴呆症的对照组患者中，斑块数量与患者年龄相关，但与他们的临床症状无关。
