Baley J E, Annable W L, Kliegman R M
J Pediatr. 1981 Mar;98(3):458-61. doi: 10.1016/s0022-3476(81)80722-6.
An attempt was made to determine the incidence and natural history of Candida endophthalmitis in the premature infant with systemic candidiasis. Each of eight premature infants were examined by indirect ophthalmoscopy within one week of their diagnosis. At this stage, four infants had multiple fluffy white lesions on both the retina and the vitreous, together with a diffuse vitreous haze. Three of the infants had interlesional and lesional-retinal vitreous strands. Three infants treated with amphotericin B and 5-fluorocytosine showed gradual disappearance of the lesions. The fourth infant died early in the course of antifungal therapy, when the eye lesions were progressing. Candida sepsis was particularly prevalent in the very low-birth-weight infant with a prolonged hospital course and treated with multiple broad-spectrum antibiotics. The course of the eye lesions indicates a good prognosis for Candida endophthalmitis, although further follow-up is necessary.
研究试图确定患有系统性念珠菌病的早产儿念珠菌性眼内炎的发病率及自然病程。八名早产儿在确诊后一周内均接受了间接检眼镜检查。在此阶段，四名婴儿的视网膜和玻璃体均出现多个蓬松的白色病变，同时伴有弥漫性玻璃体混浊。其中三名婴儿的病变间及病变与视网膜之间有玻璃体条索。三名接受两性霉素B和5-氟胞嘧啶治疗的婴儿病变逐渐消失。第四名婴儿在抗真菌治疗过程中早期死亡，当时眼部病变正在进展。念珠菌败血症在极低出生体重、住院时间延长且接受多种广谱抗生素治疗的婴儿中尤为普遍。眼部病变的病程表明念珠菌性眼内炎预后良好，不过仍需进一步随访。
