新生儿全身性真菌感染
Systemic fungal infections in neonates.
作者信息
Ng P C
机构信息
Department of Paediatrics, Chinese University of Hong Kong.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1994 Sep;71(2):F130-5. doi: 10.1136/fn.71.2.f130.
Abstract
Systemic fungal infections, previously considered to be a rare complication, are now frequently diagnosed in VLBW infants receiving intensive care. Confirming the diagnosis by laboratory tests is difficult and a high index of suspicion is required. Prompt and aggressive use of antifungal treatment is justified in a clinically septic neonate, especially those with a raised serum concentration of C reactive protein, who do not show a satisfactory response to antibiotics. The newer generation of liposomal amphotericin and azole antifungal drugs appear to be safe, effective, and well tolerated. With increasing awareness, prompt treatment, and better neonatal intensive care, the outcome of systemic fungal infection in preterm infants should improve.
摘要
全身性真菌感染以前被认为是一种罕见的并发症，现在在接受重症监护的极低出生体重儿中经常被诊断出来。通过实验室检查确诊很困难，需要高度的怀疑指数。对于临床上有败血症的新生儿，尤其是那些C反应蛋白血清浓度升高且对抗生素治疗反应不佳的新生儿，及时且积极地使用抗真菌治疗是合理的。新一代的脂质体两性霉素和唑类抗真菌药物似乎安全、有效且耐受性良好。随着认识的提高、及时的治疗以及更好的新生儿重症监护，早产儿全身性真菌感染的预后应该会得到改善。
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