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聚乙二醇对长爪沙鼠水和盐水摄入量的影响。

Effects of polyethylene glycol on water and saline intake in the Mongolian gerbil.

作者信息

Kozub F J, Hauenstein P

出版信息

J Psychol. 1981 Jan;107(1st Half):131-5. doi: 10.1080/00223980.1981.9915213.

DOI:10.1080/00223980.1981.9915213
PMID:7205704
Abstract

To establish the water balance regulatory ability of gerbils in response to a hypovolemic dipsogen, adult female gerbils (50-70 g) were injected subcutaneously with either a .9% NaCl vehicle or 10% or 30% (wt/vol) polyethylene glycol (mol wt 20,000). At each injection level one-half of the Ss had access to water, the other to .9% NaCl after injection. There was a significant increase in fluid intake associated with injection doses and Ss drank significantly more when allowed saline to drink rather than water. In Experiment II under a similar set of manipulations, hematocrit values were obtained at 12 and 24 hours after injection and showed decreasing blood volume levels which apparently served as the thirst stimulus. The results were discussed in terms of the voluntary dehydration findings of Stricker on rats and thus demonstrated the similarity of gerbils and rats in response to extracellular insult.

摘要

为了确定沙鼠对低血容量性饮水刺激的水平衡调节能力,对成年雌性沙鼠(50 - 70克)皮下注射0.9%氯化钠载体溶液或10%或30%(重量/体积)聚乙二醇(分子量20,000)。在每个注射水平,一半的实验对象注射后可饮水,另一半可饮用0.9%氯化钠溶液。液体摄入量随注射剂量显著增加,且当允许实验对象饮用盐水而非水时,它们的饮水量显著更多。在实验II中,在类似的一组操作下,在注射后12小时和24小时获取血细胞比容值,结果显示血容量水平下降,这显然充当了口渴刺激。根据斯特里克对大鼠的自愿脱水研究结果对这些结果进行了讨论,从而证明了沙鼠和大鼠在应对细胞外损伤时的相似性。

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Effects of polyethylene glycol on water and saline intake in the Mongolian gerbil.聚乙二醇对长爪沙鼠水和盐水摄入量的影响。
J Psychol. 1981 Jan;107(1st Half):131-5. doi: 10.1080/00223980.1981.9915213.
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Effects of polyethylene glycol on water or saline intake in 30- and 50-day-old Mongolian gerbils.聚乙二醇对30日龄和50日龄蒙古沙鼠水或盐水摄入量的影响。
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