Priest J H, Chen A T, Fernhoff P M, Reidy J A, Whitsett C
J Med Genet. 1980 Aug;17(4):314-6. doi: 10.1136/jmg.17.4.314.
We report a case with non-mosaic Yq-, missing the fluorescent segment, and detected as a fetus studied for advanced maternal age. The father had a Y chromosome of average size and paternity was established wih a plausibility of 97.7% by HLA and erythrocyte antigen typing. The child had a normal male antigen typing. The child had a normal male phenotype at delivery and developmental milestones were normal through the first year of life. The Yq- showed no mitotic instability since it was retained in foreskin culture for its in vitro lifetime of 60 population doublings.
我们报告一例非嵌合型Yq-病例，其缺失了荧光片段，该病例是作为高龄产妇所怀胎儿进行检查时被发现的。父亲的Y染色体大小正常，通过HLA和红细胞抗原分型确定亲子关系的可能性为97.7%。孩子具有正常的男性抗原分型。孩子出生时具有正常的男性表型，并且在生命的第一年发育里程碑均正常。Yq-在包皮培养中经过60次群体倍增的体外存活期后仍未显示出有丝分裂不稳定性。
