Vladimirov Iu A, Kogan E M
Kardiologiia. 1981 Jan;21(1):82-5.
Evidence is provided that the following events take place in the cell in hypoxia and reoxygenation: expenditure of residual oxygen; a fall in the level of macroergic compounds; entry of calcium ions into the hyaloplasm both from the outside and from the mitochondria; activation of mitochondrial A2 phospholipase (possibly along with the other phospholipases); increase of membrane ion permeability (first phase of separation). This stage corresponds to the "irreversibility point" in cell damage because if the supply of oxygen to the cell is restored after it, the cell will not "recover" but, instead, will be damaged still more. This occurs as the result of active swelling of the mitochondria, inhibition of respiration and bioenergetic functions (the second stage of separation and loss of Ca-accumulating property by the mitochondria), irreparable damage to the cell with autolysis.
有证据表明，在缺氧和复氧过程中细胞内会发生以下事件：残余氧气的消耗；高能化合物水平下降；钙离子从细胞外和线粒体进入透明质；线粒体A2磷脂酶（可能还有其他磷脂酶）的激活；膜离子通透性增加（分离的第一阶段）。这个阶段对应于细胞损伤中的“不可逆点”，因为在此之后如果恢复细胞的氧气供应，细胞不会“恢复”，反而会受到更严重的损伤。这是线粒体主动肿胀、呼吸和生物能量功能抑制（线粒体分离和失去钙积累特性的第二阶段）以及细胞自溶导致的不可修复损伤的结果。
