Wirth A, Holm G, Lindstedt G, Lundberg P A, Björntorp P
Metabolism. 1981 Mar;30(3):237-41. doi: 10.1016/0026-0495(81)90147-5.
In rats a single bout of exercise resulted in increased triiodothyronine (T3), thyroxine (T4), and triiodothyronine/reverse triiodothyronine (T3/rT3) ratio 20 hr after exercise. The effect of norepinephrine on lipolysis in vitro was potentiated. In trained rats no changes were found in T4, T3, or rT3 concentrations. The T3/rT3 ratio as well as basal and stimulated TSH concentrations decreased in comparison with sedentary, freely eating rats. Moderate food restriction to produce a body weight similar to that of trained animals caused no changes in T4, T3, or rT3 concentrations but caused a decrease in T3/rT3 and in TSH levels. Training and moderate food restriction groups were not different. T3 in vitro caused a potentiation of catecholamine induced lipolysis in trained and food-restricted animals. With aging the serum concentration of T3 decreased and that of rT3 increased. Acute and chronic exercise both exert an effect on peripheral hormonal responses of lipolysis, while they have different and opposite effects on thyroid hormone concentrations. Physical training seems to have effects in this regard similar to those of moderate energy intake restriction. The results suggest that changes in peripheral effects of thyroid hormones during training should attract more attention.
在大鼠中，单次运动后20小时，三碘甲状腺原氨酸（T3）、甲状腺素（T4）以及三碘甲状腺原氨酸/反三碘甲状腺原氨酸（T3/rT3）比值升高。去甲肾上腺素对体外脂肪分解的作用增强。在经过训练的大鼠中，未发现T4、T3或反三碘甲状腺原氨酸（rT3）浓度有变化。与久坐、自由进食的大鼠相比，T3/rT3比值以及基础和刺激状态下的促甲状腺激素（TSH）浓度均降低。适度节食以使体重与经过训练的动物相似，不会导致T4、T3或rT3浓度发生变化，但会导致T3/rT3和TSH水平降低。训练组和适度节食组之间没有差异。体外实验中，T3可增强训练和节食动物中儿茶酚胺诱导的脂肪分解。随着年龄增长，血清T3浓度降低，rT3浓度升高。急性和慢性运动均对外周脂肪分解的激素反应产生影响，而它们对甲状腺激素浓度的影响不同且相反。体育锻炼在这方面的作用似乎与适度限制能量摄入相似。结果表明，训练期间甲状腺激素外周作用的变化应引起更多关注。
