碳氟化合物。现状与未来应用。

Fluorocarbons. Current status and future applications.

作者信息

Faithfull N S

出版信息

Anaesthesia. 1987 Mar;42(3):234-42. doi: 10.1111/j.1365-2044.1987.tb03033.x.

DOI:10.1111/j.1365-2044.1987.tb03033.x

Abstract

This article presents information on medical applications of fluorocarbons. These inert chemicals have a high solubility for the respiratory gases and, in emulsified form, are present in the oxygen-transporting plasma substitutes now undergoing clinical trials. Oxygen content is directly related to arterial partial pressure of oxygen (PaO2). Thus, although oxygen transport of Fluosol-DA 20% (FDA) is only 0.75 ml per 100 ml per 10 kPa, oxygen delivery at the tissues will be adequate in the presence of a high PaO2. FDA has a low viscosity at low shear rates and this, together with a very small emulsion particle size of 0.1 micron, helps provide improved tissue oxygenation in conditions of ischaemic hypoxia. Fluorocarbon plasma substitutes may be employed as 'blood', but may also be used for a wide range of purposes in clinical practice. This review describes some current and potential future applications.

摘要

本文介绍了碳氟化合物在医学上的应用信息。这些惰性化学物质对呼吸气体具有高溶解度，并且以乳化形式存在于目前正在进行临床试验的氧输送血浆代用品中。氧含量与动脉血氧分压（PaO2）直接相关。因此，尽管20%的氟碳代血液（FDA）的氧运输量仅为每100毫升每10千帕0.75毫升，但在高PaO2存在的情况下，组织的氧输送将是充足的。FDA在低剪切速率下具有低粘度，这与非常小的0.1微米乳液粒径一起，有助于在缺血性缺氧情况下改善组织氧合。碳氟化合物血浆代用品可以用作“血液”，但也可在临床实践中用于广泛的目的。这篇综述描述了一些当前和潜在的未来应用。