119个个体基因中的密码子频率证实，根据基因组类型，简并碱基的选择具有一致性。
Codon frequencies in 119 individual genes confirm consistent choices of degenerate bases according to genome type.
作者信息
Grantham R, Gautier C, Gouy M
出版信息
Nucleic Acids Res. 1980 May 10;8(9):1893-912. doi: 10.1093/nar/8.9.1893.
Abstract
The poor printing of our previous Figure 2 (1) is corrected. Codon usage in mRNA sequences just published is also given. A new correspondence analysis is done, based on simultaneous comparison in all mRNA of use of the 61 codons. This analysis reinforces our claim that most genes in a genome, or genome type, have the same coding strategy; that is, they show similar choices among synonymous codons, or among degenerate bases (2). Like analysis on frequency variation in the amino acids coded reveals an entirely different pattern.
摘要
我们之前图2（1）印刷质量不佳的问题已得到纠正。同时还给出了刚发表的mRNA序列中的密码子使用情况。基于对所有mRNA中61种密码子使用情况的同步比较，进行了一项新的对应分析。该分析强化了我们的观点，即一个基因组或基因组类型中的大多数基因具有相同的编码策略；也就是说，它们在同义密码子或简并碱基之间表现出相似的选择（2）。就像对编码氨基酸频率变化的分析揭示了一种完全不同的模式。
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