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[片剂药物释放动力学。第6部分:从镇咳片(作者译)中释放出青藤碱]

[The dynamics of the drug release from tablets. Part 6: Liberation of glaucine from Tussiglauzin Dragées (author's transl)].

作者信息

Pasich J, Niedworok E, Warzecha U

出版信息

Pharmazie. 1980 Dec;35(12):777.

PMID:7208580
Abstract

The liberation of glaucine hydrobromide from Tussiglauzin dragées has been verified. The release to artificial gastric juice was determined by three different procedures: method using the apparatus according to Grzesiczak, stationary-basket method and rotating-basket method. All three methods showed that the largest proportion of the drug (greater than 90%) is released within 2.5 h, the maximum amount determined by means of the rotating-basket method being 99.2%.

摘要

已证实从吐根糖浆糖衣丸中释放出氢溴酸格劳君。通过三种不同程序测定其在人工胃液中的释放情况:使用Grzesiczak装置的方法、固定篮法和旋转篮法。所有这三种方法均表明,最大比例的药物(超过90%)在2.5小时内释放,通过旋转篮法测定的最大释放量为99.2%。

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