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[糖衣丸药物释放动力学。第3部分:吲哚美辛(作者译)]

[The dynamics of the drug release from dragées. Part 3: Indometnacin (author's transl)].

作者信息

Wojdak H, Pasich J

出版信息

Pharmazie. 1980 Aug;35(8):480-1.

PMID:7433498
Abstract

The release of indomethacin from dragées has been determined by the following procedures: flow-through chamber method, stationary basket method, and rotating basket method. The maximum of release was reached within 4 hours. The data obtained with the flow-through chamber and the stationary basket method were similar, whereas those yielded by the rotating basket method were somewhat higher. Furthermore, the release rate constant and the half-life period were calculated.

摘要

吲哚美辛从糖衣丸中的释放情况已通过以下方法测定

流通池法、静置篮法和旋转篮法。4小时内达到最大释放量。通过流通池法和静置篮法获得的数据相似,而旋转篮法得到的数据略高。此外,还计算了释放速率常数和半衰期。

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