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[片剂药物释放动力学。第7部分:三种释放模型对胆甾醇酯片的比较(作者译)]

[The dynamics of the drug release from tablets. Part 7: Comparison of three liberation models on Cholestil tablets (author's transl)].

作者信息

Pasich J, Niedworok E, Zajaç M

出版信息

Pharmazie. 1980 Dec;35(12):778.

PMID:7208581
Abstract

The liberation of hymecromone from Cholestil tablets (0.2 g) has been determined by three procedures; half-change method, stationary-basket method, and rotating-basket method. The release rate was highest when determined by the rotating-basket method. The other two methods yielded comparable, but considerably lower values. Artificial gastric and intestinal juices according to the Polish Pharmacopoeia IV have been used in this study.

摘要

已通过三种方法测定了利胆醇片(0.2克)中羟甲香豆素的释放情况;半衰期法、固定篮法和旋转篮法。采用旋转篮法测定时释放速率最高。另外两种方法得到的结果相当,但数值要低得多。本研究中使用了符合波兰药典IV的人工胃液和肠液。

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