Christiansen C, Brandt N J, Ebbesen F, Sardemann H, Trolle D
Acta Neurol Scand. 1980 Sep;62(3):158-64. doi: 10.1111/j.1600-0404.1980.tb03017.x.
In a controlled prospective study performed in 16 pregnant epileptics and nine normal pregnant controls, biochemical indices of calcium homeostasis (serum calcium, serum magnesium, serum phosphate, and serum alkaline phosphatases) were determined after 18 weeks pregnancy, at birth, 8 days and 6 months after birth. Furthermore, the same indices were measured in their newborns in the first 6 months of life. In both groups of mothers the serum alkaline phosphatase rose significantly during the pregnancy (P less than 0.001), followed by a significant fall after the births (epileptics: P less than 0.05, controls: P less than 0.001), but the epileptic mothers had significantly higher initial serum alkaline phosphatase levels than the controls (P less than 0.05). In both groups of newborns a dramatical fall in serum calcium was observed in the first day of life (P less than 0.001), followed by a normalization after 1 month. The serum alkaline phosphatases doubled between day 8 and day 30 in both groups (P less than 0.001). In the standing debate whether epileptics should be treated prophylactically with vitamin D, the present study indicates that pregnancy in epileptics does not call for extra vitamin D supply, and their newborns do not develop more severe hypocalcemia than their controls.
在一项针对16名癫痫孕妇和9名正常孕妇对照组进行的前瞻性对照研究中，测定了妊娠18周后、分娩时、出生后8天和6个月时钙稳态的生化指标（血清钙、血清镁、血清磷和血清碱性磷酸酶）。此外，还对两组新生儿出生后头6个月内的相同指标进行了测量。两组母亲的血清碱性磷酸酶在孕期均显著升高（P<0.001），分娩后显著下降（癫痫组：P<0.05，对照组：P<0.001），但癫痫母亲的初始血清碱性磷酸酶水平显著高于对照组（P<0.05）。两组新生儿在出生第一天血清钙均显著下降（P<0.001），1个月后恢复正常。两组新生儿血清碱性磷酸酶在出生后第8天至第30天之间均翻倍（P<0.001）。在关于癫痫患者是否应预防性补充维生素D的长期争论中，本研究表明癫痫患者怀孕时不需要额外补充维生素D，且其新生儿发生的低钙血症并不比对照组更严重。
