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芬兰的肌萎缩侧索硬化症:患者、父母及祖父母的出生地

Amyotrophic lateral sclerosis in Finland: birthplaces of patients, parents and grandparents.

作者信息

Jokelainen M, Palo J

出版信息

Acta Neurol Scand. 1980 Sep;62(3):176-9. doi: 10.1111/j.1600-0404.1980.tb03019.x.

DOI:10.1111/j.1600-0404.1980.tb03019.x
PMID:7211167
Abstract

Amyotrophic lateral sclerosis (ALS) appears to be more prevalent in the southeastern part of Finland and among the war evacuees displaced from this area after the World War II than elsewhere in the country. A random sample of 31 ALS patients was chosen and the birthplaces of their ancestors traced back in two generations to find out whether there would be any tendency of clustering in certain regions of the country. No such trend was found. This finding speaks against a genetically determined tendency for the disease.

摘要

肌萎缩侧索硬化症(ALS)在芬兰东南部以及二战后从该地区撤离的战争难民中似乎比该国其他地区更为普遍。选取了31名ALS患者的随机样本,并追溯其两代祖先的出生地,以确定该国某些地区是否存在聚集倾向。未发现此类趋势。这一发现反驳了该疾病由基因决定的倾向。

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