McComb D J, Kovacs K
Acta Endocrinol (Copenh). 1978 Nov;89(3):521-9. doi: 10.1530/acta.0.0890521.
Fifteen sparsely granulated prolactin-producing adenomas and 10 nontumourous adenohypophyses, removed by surgical hypophysectomy, have been studied using morphometry at the electron microscopic level. Compared to non-tumourous prolactin cells, sparsely granulated adenomatous prolactin cells showed a significant decrease in diameter and volume density of secretory granules and an increased volume density of rough-surfaced endoplasmic reticulum and Golgi apparatus. The volume density of mitochondria remained unchanged. These results indicate that the cells of the adenoma are in a highly active functional state. It appears that the equilibrium between hormone synthesis, storage and release is altered in adenomatous prolactin cells.
通过手术垂体切除术切除的15例颗粒稀疏的催乳素分泌腺瘤和10例非肿瘤性腺垂体，已在电子显微镜水平上进行了形态计量学研究。与非肿瘤性催乳素细胞相比，颗粒稀疏的腺瘤性催乳素细胞的分泌颗粒直径和体积密度显著降低，糙面内质网和高尔基体的体积密度增加。线粒体的体积密度保持不变。这些结果表明腺瘤细胞处于高度活跃的功能状态。腺瘤性催乳素细胞中激素合成、储存和释放之间的平衡似乎发生了改变。
