Schmidt L H
Am J Trop Med Hyg. 1981 Jan;30(1):20-5. doi: 10.4269/ajtmh.1981.30.20.
A comparison has been made of the capacities of chloroquine and quinine to serve as companions to primaquine in curing established infections with sporozoites of the M or B strains of Plasmodium cynomolgi in rhesus monkeys. The results indicated that chloroquine was slightly but consistently more effective than quinine in this role. This finding provides support for use of chloroquine as the companion blood schizonticide in the current experimental animal-based search for improved tissue schizonticidal drugs, and bolsters the rather tenuous base for clinical use of this 4-aminoquinoline, rather than quinine, as a companion to primaquine in suppressive-curative and radical-curative regimens.
已对氯喹和奎宁作为伯氨喹的辅助药物，用于治愈恒河猴体内食蟹猴疟原虫M或B株子孢子所致已确立感染的能力进行了比较。结果表明，在这一作用中，氯喹比奎宁略有效且效果持续稳定。这一发现为在当前基于实验动物寻找改良组织裂殖体杀灭药物的研究中使用氯喹作为辅助血液裂殖体杀灭剂提供了支持，并加强了将这种4-氨基喹啉而非奎宁作为伯氨喹在抑制性治愈和根治性治愈方案中的辅助药物用于临床的相当薄弱的依据。
