Morris-Jones W, Preston F E, Greaney M, Chatterjee D K
Ann Surg. 1981 Apr;193(4):462-6. doi: 10.1097/00000658-198104000-00011.
Thirty-five patients with gangrene or pregangrene of the feed associated with palpable peripheral pulses have been treated with the platelet suppressive drugs aspirin and dipyridamole. Sulphinpyrazone was substituted for two patients who could not tolerate aspirin. Complete reversal of the signs and symptoms occurred in more than 50% of the treated patients. Recurrence of pain occurred in the five patients in whom antiplatelet therapy was discontinued. Reversal of symptoms was again achieved by reintroduction of the drugs. An increased incidence of spontaneous platelet aggregation and hypersensitive platelets was observed in those patients who responded to platelet suppressive therapy. These results indicate that platelet suppressive therapy is of therapeutic value in selected patients with peripheral gangrene.
35例足部坏疽或濒于坏疽且可触及外周脉搏的患者接受了血小板抑制药物阿司匹林和双嘧达莫治疗。有2例不能耐受阿司匹林的患者换用了磺吡酮。超过50%的接受治疗的患者体征和症状完全逆转。5例停用抗血小板治疗的患者疼痛复发。重新使用这些药物后症状再次得到逆转。在对血小板抑制治疗有反应的患者中观察到自发血小板聚集增加和血小板超敏。这些结果表明，血小板抑制治疗对选定的外周坏疽患者具有治疗价值。
