Fodstad O, Pihl A
Int J Cancer. 1978 Nov 15;22(5):558-63. doi: 10.1002/ijc.2910220509.
The effect of ricin and abrin on the survival of mice treated with L1210 leukemic cells intraperitoneally or intravenously was studied. In mice given 1 X 10(5) L1210 leukemia cells intraperitoneally a single dose of ricin (2.1 microgram/kg) intraperitoneally gave the best results, an increased life span (ILS) of 59%. Abrin also increased the life span of such animals although to a lesser extent. The effect of ricin was superior to that of 5-fluorouracil, but inferior to that of adriamycin, which gave a maximum ILS of 280%. In mice given L1210 cells intravenously no increase in life span was obtained with ricin, abrin or adiramycin, whereas 5-fluorouracil gave an ILS of 40-50%. In spleen colony assays the differential effect of ricin and abrin on the proliferative capacity of normal hematopoietic and leukemic colony-forming cells in bone marrow was studied. The differential effect of ricin was as good as that of adriamycin and considerably better than that of 5-fluorouracil. Abrin had a much smaller effect than ricin on both normal and leukemic cells. The effect of abrin on the leukemic cells was too small to be of therapeutic value. The results warrant exploration of the use of ricin in the treatment of human leukemia.
研究了蓖麻毒素和相思子毒素对经腹腔或静脉注射L1210白血病细胞的小鼠存活率的影响。给小鼠腹腔注射1×10⁵个L1210白血病细胞后，腹腔注射单剂量蓖麻毒素（2.1微克/千克）效果最佳，寿命延长（ILS）达59%。相思子毒素也能延长此类动物的寿命，不过程度较小。蓖麻毒素的效果优于5-氟尿嘧啶，但不如阿霉素，阿霉素的最大ILS为280%。给小鼠静脉注射L1210细胞后，蓖麻毒素、相思子毒素或阿霉素均未使寿命延长，而5-氟尿嘧啶的ILS为40%-50%。在脾集落试验中，研究了蓖麻毒素和相思子毒素对骨髓中正常造血和白血病集落形成细胞增殖能力的差异影响。蓖麻毒素的差异效果与阿霉素相当，且明显优于5-氟尿嘧啶。相思子毒素对正常细胞和白血病细胞的影响均远小于蓖麻毒素。相思子毒素对白血病细胞的影响过小，无治疗价值。这些结果值得探索蓖麻毒素在治疗人类白血病中的应用。
