一名原发性血小板增多症患者存在复杂的费城染色体1易位。
A complex Ph1 translocation in a patient with primary thrombocythaemia.
作者信息
Fitzgerald P H, McEwan C, Fraser J, Beard M E
出版信息
Br J Haematol. 1981 Apr;47(4):571-5. doi: 10.1111/j.1365-2141.1981.tb02686.x.
Abstract
Routine blood examination of a 27-year-old female revealed a platelet count of 2000 X 10(9)/l. Bone marrow cells showed the Philadelphia chromosome which was one product of a complex rearrangement of chromosomes 9, 22 and X. Her platelet count was lowered by plateletphoresis and chemotherapy. She remains in good health 19 months later, but her thrombocythaemia is considered to be an early manifestation of chronic myeloid leukaemia.
摘要
一名27岁女性的常规血液检查显示血小板计数为2000×10⁹/L。骨髓细胞显示有费城染色体，它是9号、22号和X染色体复杂重排的产物之一。通过血小板分离术和化疗，她的血小板计数降低。19个月后她仍身体健康，但她的血小板增多症被认为是慢性髓性白血病的早期表现。
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