猴和人脑中动脉的非肾上腺素能、非胆碱能神经支配。
Non-adrenergic, non-cholinergic innervation in monkey and human cerebral arteries.
作者信息
Toda N
出版信息
Br J Pharmacol. 1981 Feb;72(2):281-3. doi: 10.1111/j.1476-5381.1981.tb09126.x.
Abstract
1 Transmural electrical stimulation (0.5 to 20 Hz) and nicotine (10(-4) M) produced relaxations of helically-cut strips of monkey and human cerebral arteries, contracted with prostaglandin F2 alpha. 2 The relaxation induced by electrical stimulation was suppressed or abolished by tetrodotoxin, while the nicotine-induced relaxation was abolished by hexamethonium but was unaffected by tetrodotoxin. Both relaxation was abolished by hexamethonium but was unaffected by tetrodotoxin. Both relaxations were not attenuated by beta-adrenoceptor antagonists and atropine. 3 These findings may indicate that large cerebral arteries of the monkey and man are innervated by non-adrenergic, non-cholinergic nerves, excitation of which liberates unknown vasodilator substance(s).
摘要
1 透壁电刺激（0.5至20赫兹）和尼古丁（10⁻⁴摩尔）可使与前列腺素F2α收缩的猴和人脑血管螺旋形切片条产生舒张。2 电刺激诱导的舒张被河豚毒素抑制或消除，而尼古丁诱导的舒张被六甲铵消除，但不受河豚毒素影响。两种舒张均被六甲铵消除，但不受河豚毒素影响。两种舒张均不被β肾上腺素能受体拮抗剂和阿托品减弱。3 这些发现可能表明，猴和人的大脑大动脉由非肾上腺素能、非胆碱能神经支配，其兴奋可释放未知的血管舒张物质。
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本文引用的文献
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3
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