Raghavan D, Barrett A
Cancer. 1980 Sep 1;46(5):1187-91. doi: 10.1002/1097-0142(19800901)46:5<1187::aid-cncr2820460518>3.0.co;2-2.
A series of malignant seminomas of the mediastinum is presented and compared with previously reported series. The difficulty of conclusively excluding occult primary gonadal disease is noted. Primary mediastinal seminomas are associated with a better prognosis than teratomas of this site, mainly because of their radiosensitivity. A case report of a patient with mediastinal seminoma and two congenital abnormalities (ventricular septal defect and congenital absence of a thoracic hemivertebra) is presented and its relationship to the possible origin of these tumors discussed.
本文报告了一系列纵隔恶性精原细胞瘤，并与先前报道的系列进行了比较。指出了明确排除隐匿性原发性性腺疾病的困难。原发性纵隔精原细胞瘤的预后优于该部位的畸胎瘤，主要是因为它们对放疗敏感。本文还报告了一例患有纵隔精原细胞瘤并伴有两种先天性异常（室间隔缺损和先天性胸半椎体缺如）的患者，并讨论了这些肿瘤可能的起源与该病例的关系。
