Hénocq E, Gaillard J
Clin Allergy. 1981 Jan;11(1):13-20. doi: 10.1111/j.1365-2222.1981.tb01560.x.
The infiltration by basophils into delayed hypersensitivity skin test sites was examined in patients with atopic dermatitis, contact dermatitis and in normal healthy persons. Atopic dermatitis patients, with large amounts of IgE, injected intradermally with staphylococcal antigens showed reactions that were more transient and erythematous than those of normal persons. On histological examination there were numerous, degranulating basophils among the perivascular mononuclear cells. Normal persons, with small amounts of IgE showed typical mononuclear cell infiltration and few basophils. Patients with contact dermatitis, one with much IgE, responded to patch tests to potassium dichromate or to nickel sulphate by delayed type reactions, but on histology, two of the four patients showed a significant infiltration by basophils. It is considered that the erythematous response to the antigen in atopic dermatitis patients is related to the basophil infiltration.
对特应性皮炎患者、接触性皮炎患者以及正常健康人进行了嗜碱性粒细胞浸润至迟发型超敏皮肤试验部位情况的检查。特应性皮炎患者体内有大量IgE，皮内注射葡萄球菌抗原后，其反应比正常人更短暂且更易出现红斑。组织学检查显示，血管周围单核细胞中有大量脱颗粒的嗜碱性粒细胞。IgE含量少的正常人表现出典型的单核细胞浸润，嗜碱性粒细胞较少。接触性皮炎患者中，有一名患者IgE含量高，对重铬酸钾或硫酸镍的斑贴试验呈迟发型反应，但组织学检查显示，四名患者中有两名出现了明显的嗜碱性粒细胞浸润。据认为，特应性皮炎患者对抗原的红斑反应与嗜碱性粒细胞浸润有关。
