Sainte-Laudy J, Henocq E
Laboratoire d'Immunologie et d'Allergologie, Paris, France.
Agents Actions. 1990 Apr;30(1-2):250-3. doi: 10.1007/BF01969052.
We compared by basophil degranulation and histamine release the reactivity to protein A and anti-IgE of the basophils from 3 groups of patients: group I (blood donors), group II (rhinitis) and group III (atopic dermatitis). We demonstrated that histamine release and basophil degranulation gave tightly correlated results and that by both methods group III was significantly (p less than 0.01) more sensitive to the effectors than the two other groups. Protein A and anti-IgE stimulation curves showed a rebound effect at low concentrations of effectors. This was, however, only significant (p less than 0.01) for group III. Bacterial hypersensitivity may be IgE-mediated and may be related to the increased sensitivity to bacterial antigens and the severity of atopic dermatitis in patients infected by Staphylococcus aureus.
我们通过嗜碱性粒细胞脱颗粒和组胺释放比较了3组患者的嗜碱性粒细胞对蛋白A和抗IgE的反应性：第一组（献血者）、第二组（鼻炎患者）和第三组（特应性皮炎患者）。我们证明组胺释放和嗜碱性粒细胞脱颗粒结果密切相关，并且通过这两种方法，第三组对效应物的敏感性显著高于其他两组（p<0.01）。蛋白A和抗IgE刺激曲线在效应物低浓度时显示出反弹效应。然而，这仅在第三组中具有显著性（p<0.01）。细菌超敏反应可能是IgE介导的，并且可能与感染金黄色葡萄球菌的患者对细菌抗原的敏感性增加以及特应性皮炎的严重程度有关。
