A mathematical model for the liver uptake and excretion of 99mTc-diethyl IDA.

A mathematical model for the liver uptake and excretion of 99mTc-diethyl IDA has been formulated and data from four patient studies have been fitted to the model, resulting in values for the model parameters. The model includes compartments for blood, extravascular space, hepatocytes, bile ducts, and kidneys. The parameter values obtained reflect a rapid exchange between blood and extravascular space and a significant reverse flow of the radiopharmaceutical from the liver to the blood.