Ozker K, Urgancioğlu I
Eur J Nucl Med. 1981 Apr;6(4):173-6. doi: 10.1007/BF00253169.
99mTc-Gentamicin complex, a new agent for renal studies, is prepared by the reduction of pertechnetate by stannous chloride. Organ distribution in rats and paper chromatography with Whatman 3MM paper [developed in n-butanol, acetic acid, and water (4:1:1)] were favored as analytical tools for determination of labeling parameters of 99mTc-Gentamicin. A higher concentration of stannous ion is responsible for the formation of insoluble technetium species which concentrate in the liver. The mean kidney: liver ratio of 10.4:1 was obtained 1 h after injection. This confirms that scintigraphic delineation of kidneys is highly satisfactory.
99mTc-庆大霉素复合物是一种用于肾脏研究的新型制剂，它是通过氯化亚锡还原高锝酸盐制备而成。大鼠体内的器官分布以及使用Whatman 3MM纸进行的纸色谱分析（展开剂为正丁醇、乙酸和水（4:1:1））被用作测定99mTc-庆大霉素标记参数的分析工具。较高浓度的亚锡离子会导致不溶性锝物种的形成，这些物种会在肝脏中富集。注射后1小时，肾脏与肝脏的平均比值为10.4:1。这证实肾脏的闪烁显像描绘非常令人满意。
