Lohse J, Vérnie H J, Sarles H
Digestion. 1981;21(3):125-32. doi: 10.1159/000198553.
To determine the solubility of pancreatic stones, in vitro experiments were performed by using the anaerobic percolation method. During steady-state conditions an inverse relationship between size and solubility in 150 mM NaCl was observed. The effects of several solvents on pancreatic stones solubility were studied: albumin induced a concentration-dependent increase, while bicarbonate induced a concentration-dependent decrease. Citrate dramatically increased the solubility of pancreatic stones, an increase was not antagonized by adding bicarbonate. Total in vitro dissolution of 50 mg pancreatic stones was attempted by percolating 150 mM NaCl or 3.9 mM citrate, a concentration which can be reached in pancreatic juice during intraduodenal infusion of citrate. Extrapolated time of total dissolution was 60 days with NaCl percolation, while actual time with citrate percolation was 25 days. The potential usefulness of citrate treatment of chronic calcified pancreatitis is discussed.
为了确定胰石的溶解度，采用厌氧渗滤法进行了体外实验。在稳态条件下，观察到在150 mM NaCl中，胰石尺寸与溶解度呈负相关。研究了几种溶剂对胰石溶解度的影响：白蛋白可引起浓度依赖性增加，而碳酸氢盐则引起浓度依赖性降低。柠檬酸盐显著增加了胰石的溶解度，添加碳酸氢盐并未拮抗这种增加。通过渗滤150 mM NaCl或3.9 mM柠檬酸盐（十二指肠内输注柠檬酸盐时胰液中可达到的浓度）尝试使50 mg胰石完全体外溶解。用NaCl渗滤时，完全溶解的外推时间为60天，而用柠檬酸盐渗滤时实际时间为25天。文中讨论了柠檬酸盐治疗慢性钙化性胰腺炎的潜在用途。
