Lohse J, Vérine H J, Charbit J J, Sarles H
Digestion. 1981;21(4):198-204. doi: 10.1159/000198563.
In a previous study, we found that pancreatic stones could be dissolved in vitro by a citrate solution. We then decided to look for the possible secretion of citrate into the pancreatic juice, and to find a means of increasing it. Pancreatic juice secretion was collected in Thomas fistula dogs submitted to four protocols: basal conditions, secretin stimulation (0.5 and 2.0 U . kg-1 . h-1), caerulein boluses (25 and 100 ng . kg-1) superimposed on 0.5 U . kg-1 . h-1 secretion and intraduodenal citrate infusion (1.05 mmol . kg-1 . h-1). Under basal conditions mean citrate output per 15 min was 0.11 +/- 0.02 mumol. During secretin and caerulein stimulation, citrate output paralleled that of protein, and a linear regression was calculated: Ycitrate = -0.013 + 0.019 Xprotein (mumol/mg). Intraduodenal citrate infusion induced a sharp increase in citrate output which reached 11.5 mumol/15 min, but only 0.12% of the infused citrate amount was secreted into pancreatic juice during 1 h.
在先前的一项研究中，我们发现胰石在体外可被柠檬酸盐溶液溶解。随后，我们决定探寻柠檬酸盐向胰液中的可能分泌情况，并找到增加其分泌的方法。在接受四种实验方案的托马斯瘘管犬中收集胰液分泌：基础条件、促胰液素刺激（0.5和2.0 U·kg⁻¹·h⁻¹）、在0.5 U·kg⁻¹·h⁻¹分泌基础上叠加蛙皮素推注（25和100 ng·kg⁻¹）以及十二指肠内输注柠檬酸盐（1.05 mmol·kg⁻¹·h⁻¹）。在基础条件下，每15分钟的平均柠檬酸盐输出量为0.11±0.02 μmol。在促胰液素和蛙皮素刺激期间，柠檬酸盐输出与蛋白质输出平行，并计算出线性回归方程：Y柠檬酸盐 = -0.013 + 0.019 X蛋白质（μmol/mg）。十二指肠内输注柠檬酸盐导致柠檬酸盐输出急剧增加，达到11.5 μmol/15分钟，但在1小时内仅有0.12%的输注柠檬酸盐量分泌到胰液中。
