Zweerink H J, Stanton L W
Infect Immun. 1981 Feb;31(2):624-30. doi: 10.1128/iai.31.2.624-630.1981.
Radioimmunoprecipitation assays were used to identify antibodies against a number of herpes simplex virus type 1-specific antigens in serum samples from individuals with recurrent facial herpes virus infections and from seropositive individuals without recurrent infections. Individuals with recurrent infections contributed three sequential serum samples each: immediately after the appearance of lesions, 3 weeks later, and 3 months later. Antibodies against at least 18 viral polypeptides were present in all positive sera: these included antibodies against the major nucleocapsid polypeptide (approximate molecular weight, 150,000) and against two glycopolypeptides with molecular weights of 115,000 to 130,000. No significant differences were observed between the serum samples in regard to their virus-specific antibody composition. The high-molecular-weight glycopolypeptides were partially purified and used in quantitative titration experiments. All sera tested were equally reactive with this material. It was concluded that under the experimental conditions an individual's susceptibility to recurrent herpetic infections could not be correlated with quantitative or qualitative changes in the levels of virus-specific antibodies.
采用放射免疫沉淀试验，对复发性面部疱疹病毒感染个体以及无复发性感染的血清阳性个体的血清样本中，针对多种1型单纯疱疹病毒特异性抗原的抗体进行鉴定。复发性感染个体每人提供三份连续的血清样本：皮损出现后立即采集、3周后采集以及3个月后采集。所有阳性血清中均存在针对至少18种病毒多肽的抗体：其中包括针对主要核衣壳多肽（近似分子量为150,000）以及针对两种分子量为115,000至130,000的糖多肽的抗体。在血清样本的病毒特异性抗体组成方面未观察到显著差异。对高分子量糖多肽进行了部分纯化，并用于定量滴定实验。所有检测的血清与该物质的反应性相同。得出的结论是，在实验条件下，个体对复发性疱疹感染的易感性与病毒特异性抗体水平的定量或定性变化无关。
