Hensle T W, Prout G R, Griffin P
J Urol. 1977 Oct;118(4):609-11. doi: 10.1016/s0022-5347(17)58122-7.
Minocycline, a broad-spectrum, highly lipid soluble tetracycline that has generated interest in the treatment of chronic prostatitis, was evaluated for its possible ability to be concentrated in benign prostatic hyperplasia. Drug levels in the prostate, plasma, fat, muscle and urine were measured in patients undergoing open prostatectomy after preoperative intravenous minocycline. The concentrations of the drug in the prostate and serum were close (4.16 versus 3.01 microgram. per gm.), while drug levels in striated muscle and fat were consistently lower (2.92 and 0.77 microgram. per gm). Higher preoperative doses of drug yielded higher tissue levels. Drug delivery closer temporally to the operation yielded higher serum and prostatic levels as opposed to striated muscle and fat, suggesting a rapid diffusion of the drug into benign prostatic hyperplasia.
米诺环素是一种广谱、脂溶性高的四环素类药物，已引起人们对其治疗慢性前列腺炎的兴趣，本研究评估了它在良性前列腺增生中可能的富集能力。对术前静脉注射米诺环素后接受开放性前列腺切除术的患者，测定其前列腺、血浆、脂肪、肌肉和尿液中的药物水平。药物在前列腺和血清中的浓度相近（分别为每克4.16微克和3.01微克），而在横纹肌和脂肪中的药物水平则一直较低（分别为每克2.92微克和0.77微克）。术前较高剂量的药物可使组织中的药物水平更高。与横纹肌和脂肪相比，在手术时间上更接近给药时，血清和前列腺中的药物水平更高，这表明药物能快速扩散到良性前列腺增生组织中。
