Patrone F, Dallegri F, Maggi A M, Rapetto C, Lanzi G
Res Exp Med (Berl). 1981;178(3):257-62. doi: 10.1007/BF01851015.
The effects of the sulfydryl donor drug N-(2-mercaptopropionyl)-glycine (MPG) on neutrophil chemotaxis, adhesiveness, phagocytosis, and hexose monophosphate shunt activity were investigated in vitro. The drug significantly enhanced all the neutrophil functions tested when used at appropriate concentrations. The results, which are in accord with the well known inhibition of neutrophil function by sulfydryl-blocking agents, suggest the possible therapeutic usefulness of the drug in clinical conditions with defective neutrophil function.
在体外研究了巯基供体药物N-（2-巯基丙酰基）-甘氨酸（MPG）对中性粒细胞趋化性、黏附性、吞噬作用和磷酸己糖旁路活性的影响。当以适当浓度使用时，该药物显著增强了所有测试的中性粒细胞功能。这些结果与巯基阻断剂对中性粒细胞功能的众所周知的抑制作用一致，表明该药物在中性粒细胞功能缺陷的临床病症中可能具有治疗用途。
