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Residence time and accumulation of drugs in the body.

作者信息

Weiss M

出版信息

Int J Clin Pharmacol Ther Toxicol. 1981 Feb;19(2):82-5.

PMID:7216555
Abstract

This investigation presents a simple and clinically useful theory of drug accumulation based on the mean residence time of drug molecules in the plasma compartment. The parameters decay fraction and accumulation factor, defined in terms of average steady-state amount in the body, are used to characterize the pharmacokinetics of multiple dosing. These parameters are calculated for digoxin and digitoxin.

摘要

相似文献

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Residence time and accumulation of drugs in the body.
Int J Clin Pharmacol Ther Toxicol. 1981 Feb;19(2):82-5.
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