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Model-independent assessment of accumulation kinetics based on moments of drug disposition curves.

作者信息

Weiss M

出版信息

Eur J Clin Pharmacol. 1984;27(3):355-9. doi: 10.1007/BF00542175.

DOI:10.1007/BF00542175
PMID:6510464
Abstract

The bounds of the accumulation profile can be predicted on the basis of the mean disposition residence time (MDRT) of a drug. The time to reach 90% of the plateau level (t0.9) is less than 3.7 MDRT. This prediction can be improved if, in addition, the variance of disposition residence time (VDRT, CV2D = VDRT/MDRT2), or the terminal exponential coefficient (lambda), is known. For CV2D----1 or lambda MDRT----1, the time to reach steady state (t0.9) approaches 2.3 MDRT (limiting case of monoexponential drug disposition curve). Conditions are stated under which lambda can be regarded as the principal determinant of the accumulation rate.

摘要

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引用本文的文献

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本文引用的文献

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Hemodynamic influences upon the variance of disposition residence time distribution of drugs.血流动力学对药物处置停留时间分布方差的影响。
J Pharmacokinet Biopharm. 1983 Feb;11(1):63-75. doi: 10.1007/BF01061768.
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Statistical moments in pharmacokinetics.药代动力学中的统计矩
J Pharmacokinet Biopharm. 1978 Dec;6(6):547-58. doi: 10.1007/BF01062109.
7
Rapid compartment- and model-independent estimation of times required to attain various fractions of steady-state plasma level during multiple dosing of drugs obeying superposition principle and having various absorption or infusion kinetics.在多次给药过程中，对遵循叠加原理且具有不同吸收或输注动力学的药物，快速进行与房室和模型无关的稳态血浆水平不同分数达到所需时间的估计。
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Pharmacokinetics of digoxin: relationship between response intensity and predicted compartmental drug levels in man.
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