Reifler B V, Ward N, Davis C M, Freidel R O
J Clin Psychiatry. 1981 May;42(5):207-11.
Plasma levels of cis and trans thiothixene were compared to clinical response in 8 acutely schizophrenic inpatients. While absolute plasma levels did not appear to correlate with clinical condition, the data did suggest that increases or decreases in cis plasma levels correlated with corresponding improvements or deteriorations in clinical condition in thiothixene responsive patients. While the results are very preliminary, the authors suggest that future studies differentiate the cis and trans isomers, and analyze relative as well as absolute changes in plasma levels as compared to clinical changes.
比较了8例急性精神分裂症住院患者的顺式和反式硫利达嗪血浆水平与临床反应。虽然血浆绝对水平似乎与临床状况无关，但数据确实表明，在硫利达嗪反应性患者中，顺式血浆水平的升高或降低与临床状况的相应改善或恶化相关。虽然结果非常初步，但作者建议未来的研究区分顺式和反式异构体，并分析与临床变化相比血浆水平的相对以及绝对变化。
