Kim D Y, Hollister L E
J Clin Psychopharmacol. 1984 Feb;4(1):32-5.
Some treatment-resistant schizophrenics will respond to rather large doses of thiothixene, such as 120 to 400 mg/day. These patients also show higher plasma concentrations (24 to 57 ng/ml) of the drug than those who respond less well. Patients tolerated this intensive treatment equally well as more conservative programs. Chronic refractory schizophrenics may benefit from such intensive treatment in the short term, but one cannot yet be certain about long-term effects.
一些难治性精神分裂症患者会对相当大剂量的硫利达嗪产生反应，例如每天120至400毫克。这些患者体内该药物的血浆浓度（24至57纳克/毫升）也高于反应较差的患者。患者对这种强化治疗的耐受性与更为保守的治疗方案相当。慢性难治性精神分裂症患者短期内可能会从这种强化治疗中获益，但尚无法确定其长期效果。
