Smith M A, Urquhart D R, Savidge G F
J Bone Joint Surg Br. 1981 Aug;63-B(2):261-5. doi: 10.1302/0301-620X.63B2.7217153.
Five patients severely affected by haemophilia, in whom six knees showed advanced haemophilic arthropathy, have been studied. The patients presented with painful limitation of movement and increasingly frequent episodes of spontaneous bleeding in the affected knees. These all showed secondary degenerative changes and varus deformity. A Corrective osteotomy of the proximal tibia was performed under full haematological cover without complications. Follow-up ranged from 6 to 36 months, with a mean of 18 months. At follow-up all patients were free of pain and had retained their range of movement. In the three patients with a longer follow-up there was radiological improvement. The most significant feature was that there was almost complete cessation of bleeding episodes into the knee in all patients and no progression of the arthropathy. The cost benefit implications of this corrective procedure are discussed.
对5例重度血友病患者进行了研究,这些患者的6个膝关节呈现晚期血友病性关节病。患者表现为受累膝关节活动疼痛受限,且自发出血发作日益频繁。所有膝关节均出现继发性退行性改变和内翻畸形。在充分的血液学保障下对胫骨近端进行了矫正截骨术,未出现并发症。随访时间为6至36个月,平均18个月。随访时所有患者均无疼痛,且保留了活动范围。在随访时间较长的3例患者中,影像学有改善。最显著的特点是所有患者膝关节几乎完全停止出血,关节病未进展。讨论了这种矫正手术的成本效益问题。