Prodi G, Nicoletti G, De Giovanni C, Galli M C, Grilli S, Nanni P, Gola G, Rocchetta R, Orlandi C
J Cancer Res Clin Oncol. 1980;98(2):173-83. doi: 10.1007/BF00405961.
The cytoplasmic concentrations of ER, AR, PR, and GR were determined in 124 specimens of normal and abnormal endometrium and other uterine human tissues by the DCC technique. In the endometrial carcinoma group, we observed that pretreatment with MAP leads to low cellularity, higher amount of AR, lower amounts of detectable ER, GR, and PR: the last receptor was almost always absent. A positive correlation between ER presence and tumor grade of differentiation was found in endometrial tumors from hormone-untreated patients. With the value of 142 fmol/mg DNA as the cut off point between high and low binding capacity, the frequency of the single receptors within the hormone-untreated cancer group ranged from 61% to 88%; ER and PR were simultaneously present in 55% of cases (they are tightly correlated in the different biopsies with respect to frequency and amount); ER-AR-PR were present in 45% and all the four receptors in 40% of cases. Slightly higher values were found in normal endometrium collected from hormone-untreated patients.
采用葡聚糖包被活性炭（DCC）技术测定了124例正常和异常子宫内膜及其他人体子宫组织样本中的雌激素受体（ER）、雄激素受体（AR）、孕激素受体（PR）和糖皮质激素受体（GR）的胞浆浓度。在子宫内膜癌组中，我们观察到丝裂原活化蛋白激酶（MAP）预处理导致细胞数量减少、AR含量增加、可检测到的ER、GR和PR含量降低：最后一种受体几乎总是缺失。在未经激素治疗的患者的子宫内膜肿瘤中，发现ER的存在与肿瘤分化程度呈正相关。以142 fmol/mg DNA作为高结合能力和低结合能力的分界点，未经激素治疗的癌症组中单一受体的出现频率在61%至88%之间；55%的病例中同时存在ER和PR（在不同活检中，它们在频率和含量方面紧密相关）；45%的病例中存在ER-AR-PR，40%的病例中存在所有四种受体。在从未经激素治疗的患者中采集的正常子宫内膜中发现的值略高。
