通过注射用猴脑免疫的兔子的脾细胞在猴子身上产生的癫痫放电。

Epileptic discharges produced in monkeys by injection of spleen cells from rabbits immunised with monkey brain.

作者信息

Baltz M L, Ettlinger G, Parrish K, Pepys M B, Rogers S

出版信息

J Neurol Sci. 1981 Mar;49(3):335-40. doi: 10.1016/0022-510x(81)90025-3.

Abstract

Cell suspension from the spleen of rabbits immunised with monkey brain gave rise to epileptic discharges in the monkey when injected intracortically, except in the case of one injection from a rabbit not recently given a booster treatment. In contrast, cell suspensions from the spleen of unimmunised rabbits, or of a rabbit immunised with a non-brain material, in all cases failed to be effective. The epileptic discharges began about 2 weeks after injection, were variable in frequency, and lasted throughout the period of recording.

摘要

用猴脑免疫的兔子脾脏细胞悬液，经皮层内注射后可使猴子产生癫痫放电，但有一次注射的细胞悬液来自近期未接受加强治疗的兔子，此次未产生癫痫放电。相比之下，未免疫兔子的脾脏细胞悬液，或用非脑物质免疫的兔子的脾脏细胞悬液，在所有情况下均无效。癫痫放电在注射后约2周开始，频率不一，并在整个记录期间持续存在。