Lieber M M, Tomera K M, Farrow G M
J Urol. 1981 Apr;125(4):481-5. doi: 10.1016/s0022-5347(17)55079-x.
Review of the Mayo Clinic tissue registry for the years 1950 to 1979 identified 90 cases of pure, well differentiated eosinophilic granular cell renal tumors. The clinical, laboratory, pathologic and survival features of these patients were analyzed. Fifty-nine per cent of these tumors were discovered incidentally during an examination for other problems and 91 per cent were confined within the renal capsule, with no evidence of local invasion. Sixty-two patients had grade 1 and 28 had graded 2 tumors. None of the patients with grade 1 tumors developed metastases. Four of the patients with grade 2 tumors died of metastatic disease. Survival curves show no difference in survival between patients with these renal tumors, and an age and sex matched cohort. If the term renal oncocytoma is used to signify a very well differentiated (grade 1) eosinophilic granular cell renal parenchymal tumor then this study demonstrates that renal oncocytomas are non-aggressive tumors with a highly favorable prognosis.
对梅奥诊所1950年至1979年组织登记处的回顾发现了90例单纯的、高分化嗜酸性粒细胞性肾肿瘤。对这些患者的临床、实验室、病理和生存特征进行了分析。这些肿瘤中有59%是在因其他问题进行检查时偶然发现的，91%局限于肾包膜内，无局部侵犯证据。62例患者为1级肿瘤，28例为2级肿瘤。1级肿瘤患者均未发生转移。2级肿瘤患者中有4例死于转移性疾病。生存曲线显示，这些肾肿瘤患者与年龄和性别匹配的队列之间在生存方面没有差异。如果用肾嗜酸细胞瘤来表示一种高分化（1级）嗜酸性粒细胞性肾实质肿瘤，那么这项研究表明肾嗜酸细胞瘤是一种非侵袭性肿瘤，预后非常良好。
