Boismare F, Le Poncin-Lafitte M, Saligaut C, Moore N
J Pharmacol. 1981 Jan-Mar;12(1):51-7.
Hypobaric hypoxia (300 mm Hg = 7180 m) was performed during 30 min. for a day during five consecutive days in rats treated or not with naftidrofuryl (15 mg/kg- i.p. daily). A conditioned avoidance response studied on five days shows a reduction of the performances in control rats but not ir treated ones. AMP and ADP cerebral levels were unchanged in the two groups. Hypoxia induced in control rats a reduction of the catecholamine cerebral levels which was not observed in treated rats. In conclusion the protection afforded by naftidrofuryl seems to be due mainly to a reduction of the catecholamine utilization during hypoxia.
对经或未经萘呋胺酯（每日腹腔注射15mg/kg）处理的大鼠，连续5天每天进行一次30分钟的低压低氧实验（300mmHg = 海拔7180米）。对连续5天进行的条件性回避反应研究表明，未处理的对照大鼠的行为表现有所下降，但经处理的大鼠则未出现这种情况。两组大鼠大脑中的AMP和ADP水平均未发生变化。低氧导致对照大鼠大脑中的儿茶酚胺水平降低，但在经处理的大鼠中未观察到这种现象。总之，萘呋胺酯提供的保护作用似乎主要是由于其减少了低氧期间儿茶酚胺的利用。
