Brandt P, Jespersen J, Gregersen G
Nephron. 1981;27(1):15-8. doi: 10.1159/000182013.
A 34-year-old woman with a family history of pregnancy-associated thrombotic disease developed pre-eclampsia in her 8th month of pregnancy. A severe haemolytic-uraemic syndrome (HUS) developed within 24 h after spontaneous delivery. Because the plasma antithrombin-III (AT-III) was only 15% of the normal concentration, an AT-III concentrate was given intravenously. When the normal level of plasma AT-III was reached, the clinical and biochemical signs of the syndrome disappeared. Renal function and biopsy were normal within 10 days. Because complete recovery is unusual in patients with post partum HUS and no previous reports have described a rapid recovery, the case reported here suggests that infusion of an AT-III concentrate should be tried when plasma AT-III is significantly decreased.
一名有妊娠相关血栓形成疾病家族史的34岁女性，在妊娠第8个月时发生了先兆子痫。自然分娩后24小时内出现了严重的溶血性尿毒症综合征（HUS）。由于血浆抗凝血酶III（AT-III）仅为正常浓度的15%，故静脉给予AT-III浓缩物。当血浆AT-III达到正常水平时，该综合征的临床和生化体征消失。10天内肾功能及活检均正常。由于产后HUS患者完全康复并不常见，且此前没有报告描述过快速康复的情况，因此本文报告的病例提示，当血浆AT-III显著降低时，应尝试输注AT-III浓缩物。
