Sirot J, Lopitaux R, Cluzel R, Rampon S
Rev Rhum Mal Osteoartic. 1981 Jan;48(1):9-16.
The etiological diagnosis of bone and joint infections, the choice of antibiotics adapted to the responsible bacteria and the supervision of their efficacy depend mainly on the bacteriology laboratory. A routine search for the causal bacteria in various samples, e.g. synovial fluid, blood cultures, synovial biopsy, inter-vertebral disc puncture, permit etiological diagnosis in about 80% of cases. The choice of antibiotics, limited to those whose synovial and bony diffusion is known, depends on the results of in vitro studies of sensitivity of the isolated bacteria (CMI and CMB) and of the bactericidal power of the associations. The measurement of the inhibitory power or concentrations of antibiotic in synovial fluid and serum give an indication of the efficacy of the treatment.
骨与关节感染的病因诊断、根据致病细菌选择合适的抗生素以及对其疗效的监测主要依赖于细菌学实验室。对各种样本（如滑液、血培养、滑膜活检、椎间盘穿刺）进行常规的致病细菌检测，大约80%的病例可实现病因诊断。抗生素的选择限于那些已知其在滑膜和骨骼中扩散情况的药物，这取决于对分离出的细菌进行体外敏感性研究（最小抑菌浓度和最小杀菌浓度）以及联合用药杀菌能力的结果。测定滑液和血清中抗生素的抑菌能力或浓度可反映治疗效果。
